In the monograph offered to the attention of readers, for the first time in the world literature, both the theoretical foundations for creating flotocombines based on a multi-stage and generalized flotation model are considered, and practical recommendations based on the principles of biosimile. Possible schemes of flotocombines of the KBS type and special purpose are shown. New aeration systems for use in various flotation apparatus, including flotocombines, are considered. Practical examples of the use of new flotation equipment are described. It is offered to a wide range of readers, including researchers, university professors, graduate students, masters, bachelors and senior students.